Related papers:
https://www.pnas.org/content/108/49/E1293.long
https://academic.oup.com/bioinformatics/article-lookup/doi/10.1093/bioinformatics/btr638
https://academic.oup.com/bioinformatics/article/31/7/999/181503
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005324
https://www.pnas.org/content/114/34/9122